Protein Details: Gamma-aminobutyric acid receptor subunit beta-4

Protein ID

ICDB_Pro_0428

Protein Name

Gamma-aminobutyric acid receptor subunit beta-4

Gene Name

GABRB4

Organism

Gallus gallus (Chicken)

Length

488 amino acids

AlphaFoldDB

AF-P24045-F1-model_v4.pdb

Function

GABA; the major inhibitory neurotransmitter in the vertebrate brain; mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Sequence

MWTFQADRLSGIVSALAALCVACCAQSPSTGNISVVKEIVDKLLKGYDVRLRPDFGGNPVTVGMSIHISSIDQISEVNMDYTITMYFQQSWRDKRLAYNDLPLNLTLDNRVADQLWLPDTYFLNDKKSFLHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDQQNCTLEIESYGYTVDDIVFFWQGNDSAVTGMEVLELPQFTIIEQRLVSREVVFTTGSYLRLSLSFRIKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGVTTVLTMTTINTHLRETLPKIPYVKAIDVYLMGCFVFVFLALLEYAFVNYIFFGRGPRQQKKQSERISKANNERHRYEEKRVREQVDPYGNILLSTLDMNNELLATDMMSSVGDSRNSVMSFEGSGIQFRKPLASRDGFGHHPTLDRHVPLTHHAAARNRANCRLRRRSSKLKLKIPDLTDVSTIDKWSRIIFPITFGFFNLVYWLYYVN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1111/j.1471-4159.1991.tb11443.x

RefSeq

NP_001161175.1 [P24045-1]; NP_001161176.1 [P24045-2]